On February 18th 2021, A Democrat from San Francisco, California introduced a bill to decriminalize psychedelics on a state level. Senator Scott Wiener introduced Senate Bill 519 to decriminalize certain psychedelics in the interest of public health and safety and to address the failed War on Drugs.

33 states and D.C. had passed laws legalizing or decriminalizing medical marijuana with 11 states and D.C. have legalized marijuana for recreational purposes. Nine of which were through statewide citizen-initiated ballot measures and two through state legislative processes. On Tuesday, 7 initiatives covering cannabis reform were on the ballot and all of these measures passed. Arizona, Montana, New Jersey, and South Dakota have approved statewide ballot measures to legalize marijuana for personal use.