The Mechanism of DISE

DISE involves the elimination of genes that are essential for the survival of normal cells, but not for cancer cells. When normal cells lose these genes, they activate a self-destruct program that kills them. However, when cancer cells lose these genes, they continue to grow and divide.

Implications for Cancer Cells

The loss of these genes in cancer cells makes them more vulnerable to the immune system and other treatments. This vulnerability presents a potential avenue for targeted cancer therapies that could effectively combat the disease while minimizing harm to normal cells.

Potential for New Therapies

The scientists hope that the discovery of DISE could lead to the development of new therapies. By targeting the specific genes involved in this mechanism, it may be possible to create treatments that can selectively kill cancer cells, leaving healthy cells unharmed.

Conclusion

The discovery of DISE represents a significant advancement in our understanding of cancer biology. It offers a promising new approach to cancer treatment, with the potential to improve outcomes for patients while reducing the side effects associated with many current therapies.