Also known by its popular brand names Quaalude and Sopor among others, is a hypnotic sedative1. It was first synthesized in India in the 1950s and introduced into America in the 1960s. By the late '60s and '70s, it became a popular recreational drug. Medical Use and Mechanism of Action Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates. When GABA activity is increased, blood pressure drops and breathing and pulse rates slow, leading to a state of deep relaxation. In prescribed doses, Methaqualone promotes relaxation, sleepiness, and sometimes a feeling of euphoria2. Recreational Use and Abuse Methaqualone became increasingly popular as a recreational drug and club drug in the late 1960s and 1970s. It was known variously as “ludes” or “disco biscuits” due to its widespread use during the popularity of disco in the 1970s.

The substance was sold both as a free base and as a salt (hydrochloride). The landscape of drug policy in the United States is undergoing a seismic shift, and California's AB-1021 is at the epicenter. The bill, part of the 2023-2024 legislative session, challenges long-standing perceptions of several Schedule 1 drugs, including heroin, LSD, cannabis, methaqualone, peyote, and notably, psychedelics like MDMA and psilocybin. Legal Status Due to its widespread abuse and addictiveness, commercial production of Methaqualone was halted in the mid-1980s. In 1973, Methaqualone was placed in Schedule II of the Controlled Substance Act, making it difficult to prescribe and illegal to possess without a prescription2. In 1984 it was moved to the Drug Enforcement Agency (DEA) Federal Schedule I, so Quaaludes are no longer legally available in the United States.

**History and Popularity**

Methaqualone's rise and fall in popularity are quite intriguing. As you mentioned, it was initially synthesized in India in the 1950s and later introduced into the United States in the 1960s. Initially, it was considered a safer alternative to barbiturates and was used for medical purposes, primarily as a sleep aid. In the late 1960s and 1970s, it gained immense popularity as a recreational drug. It was often referred to as "ludes" or "disco biscuits" due to its association with the disco era. Its effects, which included relaxation, sleepiness, and occasional euphoria, made it a sought-after substance among those looking to unwind and have a good time.

**Mechanism of Action**

Methaqualone's mechanism of action is worth noting. Like benzodiazepines and barbiturates, it increases the activity of GABA receptors in the brain and nervous system. GABA is an inhibitory neurotransmitter that reduces neuronal excitability. When GABA activity is enhanced, it leads to a decrease in blood pressure, slowed breathing, and lowered pulse rates, ultimately resulting in a state of deep relaxation.

**Legal Status and Decline**

The popularity of Methaqualone was accompanied by a growing concern over its potential for abuse and addiction. As a result, it faced increasing legal restrictions. In 1973, it was classified as a Schedule II controlled substance, making it challenging to prescribe and illegal to possess without a prescription. By 1984, it was classified as a Schedule I controlled substance by the Drug Enforcement Agency (DEA), making it completely illegal in the United States. This legal crackdown significantly impacted the availability of Methaqualone in the market. Its commercial production was halted in the mid-1980s. Consequently, it is now quite rare to find Methaqualone on the streets in the United States. Nevertheless, there are occasional reports of it being confiscated when crossing borders. In conclusion, the story of Methaqualone serves as a cautionary tale about the rise and fall of a once-popular drug due to its potential for abuse and addiction. Its legal status and availability have been dramatically curtailed, reflecting evolving attitudes and regulations surrounding drug use and control. Conclusion While Methaqualone was initially introduced as a safe barbiturate substitute to help induce sleep, it was later shown to have addiction and withdrawal symptoms similar to other prescription barbiturates2. Today, Methaqualone is rarely encountered on the streets in the U.S., but are occasionally confiscated coming across the border.

Addiction and Withdrawal

Methaqualone's descent from a supposed safer alternative to barbiturates to a highly addictive substance is a cautionary tale. Initially, its potential for addiction and withdrawal symptoms was not fully understood. Users often experienced dependence and unpleasant withdrawal effects, much like traditional prescription barbiturates. This realization, coupled with the increasing recreational use, raised concerns about its safety and led to tighter regulations.

Changing Legal Landscape

The legal status of Methaqualone is a notable aspect of its history. As you mentioned, it was classified as a Schedule II controlled substance in 1973, making it difficult to obtain without a prescription. However, by 1984, the DEA escalated its classification to Schedule I, placing it in the same category as drugs like heroin. This change in legal status reflected a growing recognition of the risks associated with Methaqualone use.

Current Availability

Today, Methaqualone is a rare find on the streets of the United States. The combination of stringent legal restrictions and a diminishing supply has significantly reduced its presence in the recreational drug market. However, as you mentioned, there are occasional reports of it being confiscated when crossing borders, indicating that there might still be limited circulation through illicit channels.

In a broader context, the story of Methaqualone serves as a reminder of the evolving understanding and regulation of substances with the potential for abuse. It showcases the importance of continuously assessing the safety and risks of drugs, both from a medical and societal perspective. This history also highlights the need for effective drug education and addiction prevention programs to mitigate the harm associated with substance abuse.